[6] CimaVax is relatively cheap to produce and store, and has low toxicity. By continuing to use this site, you are agreeing to the new Privacy and Terms. The Cuban government and Cuban researchers have in the last 30 years pushed biotechnology and immunotherapy (also known as biotherapy or biological therapy) to the forefront. [16], An ongoing Phase II clinical trial (clinicaltrials.gov identifier NCT02955290) has been expanded to include patients with advanced, recurrent head and neck squamous-cell carcinoma, as well as patients with advanced NSCLC but with high PD-L1 levels, who will be treated with pembrolizumab in combination with CIMAvax instead of nivolumab. CubaHeal is a loyal supporter of the Republic of Cuba, the Cuban people, the Cuban revolution, and the Cuban revolutionary leadership. Cuba is well known for its cutting edge treatment of lung cancer and advances in cancer vaccines currently being tested in the United States. [8] More antibodies are raised when the vaccine is formulated with Montanide ISA 51 rather than aluminum hydroxide as an adjuvant, and when patients receive a low dose of cyclophosphamide three days before vaccine administration. [8] It has been urged that CimaVax be tested in patients with earlier-stage NSCLC cancer and in patients who are not candidates for chemotherapy, and that research be conducted to determine which subgroups of NSCLC patients do and don't respond to the vaccine. Thus CimaVax does not target the cancer cells directly, but is expected to work against these cancers by denying the cancers the growth stimulus they require. [6] In late October 2016, the United States Food and Drug Administration authorized[12] the Roswell Park Cancer Institute to conduct a PhaseI/II clinical trial of CimaVAX in patients with non-small cell lung cancer. [5] In October 2015 Serbia's Institute of Virology, Vaccines and Sera (AKA Torlak Institute) signed a memorandum for use in 30 patients as part of a study. [4], [needs update] ", "Clinical development and perspectives of CIMAvax EGF, Cuban vaccine for non-small-cell lung cancer therapy", "Safety, immunogenicity and preliminary efficacy of multiple-site vaccination with an Epidermal Growth Factor (EGF) based cancer vaccine in advanced non small cell lung cancer (NSCLC) patients", Journal of Immune Based Therapies and Vaccines, "Roswell Park gets go-ahead to test Cuban lung cancer vaccine", "CIMAvax Vaccine and Nivolumab in Treating Patients With Stage IIIB-IV Non-small Cell Lung Cancer - Full Text View - ClinicalTrials.gov", "Cuba Has a Lung Cancer Vaccine; Now U.S. The Cancer Treatment program is delivered in two phases, an induction phase of one dose every two weeks for a total of five doses, followed by a Maintenance phase. 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