The good news was that patients receiving the 1 mg dose of Oral Korsuva did experience improvement on both secondary endpoints. TheStreet Ratings rates this stock as a "sell" with a ratings score of D. The company's weaknesses can be seen in multiple areas, such as its weak operating cash flow, generally disappointing historical performance in the stock itself and feeble growth in its earnings per share. Stock Advisor launched in February of 2002. The Shelton, CT-based clinical-stage bio-pharmaceutical company announced on Thursday that the FDA placed the Phase 3 trial on hold in order to conduct a safety review. Separately, recently, TheStreet Ratings objectively rated this stock according to its "risk-adjusted" total return prospect over a 12-month investment horizon. Cara stated that this result "was statistically significant after two weeks of treatment and sustained through the 12-week treatment period.". Patients receiving a 1 mg dose of Oral Korsuva reported a reduction of 4.4 points in the weekly mean of their daily WI-NRS scores, compared to a 3.3-point reduction for patients on placebo. Let's conquer your financial goals together...faster. The big drop came after the drugmaker announced results from a phase 2 clinical study evaluating Oral Korsuva in treating chronic kidney disease … Returns as of 09/24/2020. The initial results of the safety review show that no serious adverse events have been reported in connection with the trial, the company added. The market's reaction shows that the results weren't as positive as the headlines indicated. Keith began writing for the Fool in 2012 and focuses primarily on healthcare investing topics. Now read: Axsome's AXS-12 achieves primary endpoint in mid-stage narcolepsy study; shares up 6% premarket », Axsome's AXS-12 achieves primary endpoint in mid-stage narcolepsy study; shares up 6% premarket ». The trial was halted after some patients exceeded a certain level of serum sodium levels, which triggered a stopping rule, Cara said in a statement on Thursday. Market data powered by FactSet and Web Financial Group. A Phase 2 clinical trial evaluating Cara Therapeutics' (NASDAQ:CARA) Korsuva (difelikefalin) (formerly CR845) for the treatment of pruritus (itchy skin) in patients with moderate-to-severe chronic kidney disease (CKD) met the primary endpoint.

Specifically, participants receiving the 1 mg strength of Korsuva experienced a statistically significant reduction in the weekly average of daily WI-NRS scores (scale of itching intensity) from baseline at week 12 compared to placebo (-4.4 vs. -3.3, p=0.018). Neither did the drug achieve statistically significant improvement for patients on the 1 mg dose in increasing itch-related quality-of-life endpoints on a couple of self-assessment scales. It's possible that a larger clinical study could yield very different results -- either better or worse.

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